2023
2022
2021
![D2d Publication: Effect of Vitamin D Supplementation on Kidney Function in Adults with Prediabetes: A Secondary Analysis of a Randomized Trial D2d Publication: Effect of Vitamin D Supplementation on Kidney Function in Adults with Prediabetes: A Secondary Analysis of a Randomized Trial](https://d2dstudy.org/wp-content/uploads/2021/08/qtq80-wKsZyN-470x320.jpeg)
4
Aug
Despite evidence for associations between low circulating 25(OH)D concentration and kidney disease, few clinical trials have evaluated the effect of vitamin D supplementation on kidney...
![D2d Publication: Vitamin D Supplementation for Prevention of Cancer: The D2d Cancer Outcomes (D2dCA) Ancillary Study D2d Publication: Vitamin D Supplementation for Prevention of Cancer: The D2d Cancer Outcomes (D2dCA) Ancillary Study](https://d2dstudy.org/wp-content/uploads/2021/08/qtq80-D2VSEN-470x320.jpeg)
1
Jul
Observational studies suggest that low vitamin D status may be a risk factor for cancer. In a population with prediabetes and overweight/obesity that is at...
2020
![Vitamin D Supplementation for Prevention of Type 2 Diabetes Mellitus: To D or Not to D? Vitamin D Supplementation for Prevention of Type 2 Diabetes Mellitus: To D or Not to D?](https://d2dstudy.org/wp-content/uploads/2020/10/qtq80-zMbgs0-470x320.jpeg)
19
Oct
The manuscript explains that results from recent trials are congruent with a large body of evidence from observational studies indicating that vitamin D has a role...
![D2d Publication: Intratrial Exposure to Vitamin D and New-Onset Diabetes Among Adults With Prediabetes: A Secondary Analysis From the Vitamin D and Type 2 Diabetes (D2d) Study D2d Publication: Intratrial Exposure to Vitamin D and New-Onset Diabetes Among Adults With Prediabetes: A Secondary Analysis From the Vitamin D and Type 2 Diabetes (D2d) Study](https://d2dstudy.org/wp-content/uploads/2020/10/qtq80-5AOLxi-470x320.jpeg)
5
Oct
The manuscript explains how postrandomization biases may influence the estimate of efficacy of supplemental vitamin D in diabetes prevention trials. In the Vitamin D and...
![Untangling the Gordian Knot of Vitamin D Supplementation and Type 2 Diabetes Prevention Untangling the Gordian Knot of Vitamin D Supplementation and Type 2 Diabetes Prevention](https://d2dstudy.org/wp-content/uploads/2020/03/qtq80-unHYXi-470x320.jpeg)
1
Jul
In the commentary Dr. Pittas and Dr. Balk explain that although meta-analyses increase statistical power, allowing more precise effect estimates, for them to be credible...
![D2d Publication: Implications of the Hemoglobin Glycation Index on the Diagnosis of Prediabetes and Diabetes D2d Publication: Implications of the Hemoglobin Glycation Index on the Diagnosis of Prediabetes and Diabetes](https://d2dstudy.org/wp-content/uploads/2020/01/hgi-pic-470x320.jpg)
22
Jan
This analysis used D2d data (individuals with complete screening and baseline visit data) to calculate HGI, identify demographic and clinical variables associated with HGI, and...
2019
![Results of The Primary Outcome Are Unveiled Results of The Primary Outcome Are Unveiled](https://d2dstudy.org/wp-content/uploads/2019/05/qtq80-9rtJwj-e1557951977575-470x320.jpeg)
7
Jun
A presentation of the results took place at the annual American Diabetes Association meeting in San Francisco on Friday, June 7th. Results were published in...
2018
![D2d Participant Visits Completed D2d Participant Visits Completed](https://d2dstudy.org/wp-content/uploads/2019/05/qtq80-oDUUeP-e1557946042146-470x320.jpeg)
2
Nov
The last participant study visit was completed at the Northwestern site. This is a very exciting time for both participants and researchers alike! Since the...
![D2d Publication: Financial Management of large, multi-center trials D2d Publication: Financial Management of large, multi-center trials](https://d2dstudy.org/wp-content/uploads/2018/04/approved-e1530132523201-470x320.jpg)
3
May
Randomized clinical trials that have public health implications but no or low potential for commercial gain are predominantly funded by governmental (e.g., National Institutes of...
![D2d Establishes a Participant Registry D2d Establishes a Participant Registry](https://d2dstudy.org/wp-content/uploads/2019/05/D2d-registry-card-e1557942131213-470x320.jpg)
6
Apr
A future long-term observational follow-up study (with no pills or visits) is being considered for the purpose of collecting simple health information to learn more...
![D2d Publication: Baseline characteristics of the D2d cohort D2d Publication: Baseline characteristics of the D2d cohort](https://d2dstudy.org/wp-content/uploads/2018/05/publications-glasses-470x320.jpg)
3
Mar
D2d is the largest clinical trial designed specifically to examine the causal relationship between vitamin D supplementation and the development of diabetes. D2d is also...
2017
![D2d Investigators’ Meeting D2d Investigators’ Meeting](https://d2dstudy.org/wp-content/uploads/2017/10/2017_1022_D2d_News_Feature_01-470x320.jpg)
22
Oct
The annual meeting of the D2d research team is held in Washington D.C.. On Sunday evening, Principal Investigator Dr. Pittas presents the State of D2d, which...
![Interim analysis results are reviewed Interim analysis results are reviewed](https://d2dstudy.org/wp-content/uploads/2018/02/2017_0925_D2d_News_Feature-470x320.jpg)
25
Sep
The Data and Safety Monitoring Board (DSMB) reviews the results of the interim analysis. This is a critical juncture in the conduct of any clinical...
![D2d Publication: Assessment of the NDEP diabetes prevention toolkit D2d Publication: Assessment of the NDEP diabetes prevention toolkit](https://d2dstudy.org/wp-content/uploads/2018/02/2017_0803_D2d_News_Feature-470x320.jpg)
3
Aug
The National Diabetes Education Program created the Small Steps. Big Rewards. GAME PLAN. toolkit to deliver basic type 2 diabetes prevention information to individuals at risk....
![D2d enrolls last participant D2d enrolls last participant](https://d2dstudy.org/wp-content/uploads/2018/02/2017_0208_D2d_News_Feature-470x320.jpg)
8
Feb
A patient from the New York Lenox Hospital site is the 2,423rd and last participant enrolled in D2d. The participant completed the study. Congratulations to...
2016
![D2d meets enrollment goal D2d meets enrollment goal](https://d2dstudy.org/wp-content/uploads/2018/02/2016_1216_D2d_News_Feature-470x320.jpg)
16
Dec
A participant from the Atlanta VA Medical Center site is the 2,382nd participant enrolled in D2d. The study’s recruitment goal is achieved. This is a...
![D2d Publication: Management of hemoglobin variants during hemoglobin A1c testing D2d Publication: Management of hemoglobin variants during hemoglobin A1c testing](https://d2dstudy.org/wp-content/uploads/2016/11/2016_1129_D2d_News_Feature_2-470x320.jpg)
29
Nov
When measuring HbA1c, many clinical laboratories do not report the presence of hemoglobin variants, whereas others report them only if they interfere with HbA1c measurement....
![D2d Investigators’ Meeting D2d Investigators’ Meeting](https://d2dstudy.org/wp-content/uploads/2018/02/2016_0925_D2d_News_Feature-470x320.jpg)
25
Sep
The annual meeting of the D2d research team is held in Arlington, VA. On Sunday evening, principal investigator Dr. Pittas presents the State of D2d,...
![D2d enrolls 2,000th participant D2d enrolls 2,000th participant](https://d2dstudy.org/wp-content/uploads/2018/02/2016_0627_D2d_News_Feature-470x320.jpg)
27
Jun
A participant from the Pennington Biomedical Research Center site is the 2,000th participant enrolled in D2d. The participant completed the study....
2015
![D2d enrolls 1,500th participant D2d enrolls 1,500th participant](https://d2dstudy.org/wp-content/uploads/2018/02/2015_1120_D2d_News_Feature-470x320.jpg)
20
Nov
A participant from the Northwestern University site is the 1,500th participant enrolled in D2d. The participant completed the study....
![D2d Investigators’ Meeting D2d Investigators’ Meeting](https://d2dstudy.org/wp-content/uploads/2018/02/2015_1108_D2d_News_Feature-470x320.jpg)
8
Nov
The annual meeting of the D2d research team is held in Arlington, VA. On Sunday evening, principal investigator Dr. Pittas presents the State of D2d,...
![D2d enrolls 1,000th participant D2d enrolls 1,000th participant](https://d2dstudy.org/wp-content/uploads/2018/02/2015_0420_D2d_News_Feature-470x320.jpg)
20
Apr
A participant from the MedStar Community Clinical Research Center D2d site is the 1,000th participant enrolled in D2d. The participant completed the study. ...
2014
![DSMB is pleased with recruitment progress DSMB is pleased with recruitment progress](https://d2dstudy.org/wp-content/uploads/2018/04/time-fore-review-470x320.jpeg)
20
Nov
The D2d Data and Safety Monitoring Board (DSMB) meets twice a year to review the study’s progress. At this meeting, the DSMB is impressed with...
![D2d Investigators’ Meeting D2d Investigators’ Meeting](https://d2dstudy.org/wp-content/uploads/2018/02/2014_1117_D2d_News_Feature-470x320.jpg)
17
Nov
The annual meeting of the D2d research team is held in Crystal City, MD. On Sunday evening, principal investigator Dr. Pittas presents the State of...
![First D2d Publication: Rationale and Design of D2d First D2d Publication: Rationale and Design of D2d](https://d2dstudy.org/wp-content/uploads/2018/02/2014_0909_D2d_News_Feature-470x320.jpg)
15
Sep
The D2d team publishes its first manuscript related to D2d: The rationale and Design of the Vitamin D and Type 2 Diabetes (D2d) Study: A...
![D2d enrolls 500th participant D2d enrolls 500th participant](https://d2dstudy.org/wp-content/uploads/2018/02/2014_0828_D2d_News_Feature-470x320.jpg)
28
Aug
A participant at the Atlanta VA Medical Center site is the 500th participant enrolled in D2d. The participant completed the study....
2013
![D2d enrolls 1st participant D2d enrolls 1st participant](https://d2dstudy.org/wp-content/uploads/2017/02/1st-participant-470x320.png)
1
Nov
A patient at the University of Kansas site is the 1st participant enrolled in D2d. The participant is still in D2d....
![Press release on D2d Press release on D2d](https://d2dstudy.org/wp-content/uploads/2018/02/press-release-e1519336792266-470x320.jpg)
21
Oct
Tufts Medical Center (where the D2d Coordinating Center is based) and NIDDK coordinate a press release to announce the official start of D2d activities....
![Participant recruitment begins Participant recruitment begins](https://d2dstudy.org/wp-content/uploads/2018/02/2013_1015_D2d_News_Feature-470x320.jpg)
15
Oct
D2d begins screening people at high risk for diabetes to join D2d. Screening takes place in many medical centers throughout the United States. The first...
![U.S. government shutdown delays the start of recruitment U.S. government shutdown delays the start of recruitment](https://d2dstudy.org/wp-content/uploads/2018/02/Sorry-closed-e1519336476327-470x320.jpg)
1
Oct
The U.S. federal government enters a shutdown because neither legislation appropriating funds for fiscal year 2014 nor a continuing resolution for the interim authorization of...
![D2d becomes the first NIDDK supported trial to use IRBShare D2d becomes the first NIDDK supported trial to use IRBShare](https://d2dstudy.org/wp-content/uploads/2018/02/2013_0919_D2d_News_Feature-470x320.jpg)
19
Sep
Obtaining IRB approval from each separate collaborating clinical site has long been considered a major reason for delaying the start of activities in multi-center trials....
![Investigators’ Kick-off meeting Investigators’ Kick-off meeting](https://d2dstudy.org/wp-content/uploads/2018/02/2013_0710_D2d_News_Feature-470x320.jpg)
9
Jul
The first meeting of the D2d Research Group is held in Bethesda, MD. Investigators and coordinators from all sites and all supporting units (e.g., central laboratory,...
![U01 grant to conduct D2d is formally awarded U01 grant to conduct D2d is formally awarded](https://d2dstudy.org/wp-content/uploads/2013/06/053014_mf_3560v-sheehan-pittas-e1519324220891-470x320.jpg)
1
Jun
Tufts Medical Center receives the U01 cooperative agreement grant to fund and conduct D2d. The grant is awarded by NIDDK and the NIH Office of...
![The D2d DSMB inaugural meeting takes place The D2d DSMB inaugural meeting takes place](https://d2dstudy.org/wp-content/uploads/2013/05/DSMB-meeting-e1519336068636-470x320.jpg)
31
May
The inaugural meeting of the D2d Data Safety Monitoring Board (DSMB) takes place in Bethesda, MD. The core D2d team – composed of Dr. Pittas...
2012
![U01 cooperative agreement grant application undergoes scientific review U01 cooperative agreement grant application undergoes scientific review](https://d2dstudy.org/wp-content/uploads/2018/02/2012_0605_D2d_News_Feature-470x320.jpg)
14
Sep
The U01 grant application seeking funding for D2d undergoes a highly favorable scientific peer review by a NIH Special Emphasis Study Section, specifically convened to...
![U01 cooperative agreement grant is submitted U01 cooperative agreement grant is submitted](https://d2dstudy.org/wp-content/uploads/2017/02/binder-e1519317908368-470x320.png)
5
Jun
The D2d team submits a U01 grant application to NIH for funding to conduct D2d. Assembling a 1,140-page grant application was a Herculean effort by...
![Progress of U34 planning phase is reviewed favorably Progress of U34 planning phase is reviewed favorably](https://d2dstudy.org/wp-content/uploads/2018/02/2012_0330_D2d_News_Feature-470x320.jpg)
30
Mar
An External Evaluation Committee convened by NIDDK reviews the progress of the U34 planning phase. The Committee concludes that the D2d team has made excellent...
![Association between higher blood level of vitamin D and lower risk of diabetes among adults with prediabetes is reported Association between higher blood level of vitamin D and lower risk of diabetes among adults with prediabetes is reported](https://d2dstudy.org/wp-content/uploads/2012/03/DPP_new-470x320.png)
1
Mar
This observational study was to assess the longitudinal association between vitamin D status – assessed by blood level of 25-hydroxyvitamin D – and risk of developing diabetes among...
2011
![The Origin of the D2d logo The Origin of the D2d logo](https://d2dstudy.org/wp-content/uploads/2013/07/d2d-logo-without-white-background1-470x320.png)
11
Aug
The D2d logo was created in the summer of 2011. The three elements (D, 2, d) were chosen to represent the D2d study in the...
![CaDDM clinical trial results are published CaDDM clinical trial results are published](https://d2dstudy.org/wp-content/uploads/2018/02/CADDM-e1519317508818-470x320.png)
1
Aug
Results of the Vitamin D and Calcium Homeostasis for Prevention of Type 2 Diabetes (CaDDM) study support a mechanistic link between vitamin D and diabetes...
![U34 planning grant is awarded U34 planning grant is awarded](https://d2dstudy.org/wp-content/uploads/2011/07/NIH_NIDDK-470x320.jpg)
20
Jul
Dr. Pittas and colleagues are awarded a Multi-Center Clinical Study Implementation Planning Cooperating Agreement (U34) grant. The NIDDK-supported grant provides support to a core team...
2010
![U34 planning grant application undergoes scientific review U34 planning grant application undergoes scientific review](https://d2dstudy.org/wp-content/uploads/2018/04/conference-meeting-470x320.jpg)
10
Oct
The U34 grant application undergoes a highly favorable scientific peer review by an NIH Special Emphasis Study Section, specifically convened to review the application. Over...
![Association between higher blood level of vitamin D and lower risk of diabetes among women is reported Association between higher blood level of vitamin D and lower risk of diabetes among women is reported](https://d2dstudy.org/wp-content/uploads/2018/02/2010_0915_D2d_News_Feature-470x320.jpg)
15
Sep
An observational study in the Nurses’ Health Study – a longitudinal cohort of women – supports an association between higher blood level of vitamin D and...
![U34 planning grant application is submitted U34 planning grant application is submitted](https://d2dstudy.org/wp-content/uploads/2018/02/2010_0730_D2d_News_Feature-470x320.jpg)
30
Jul
Dr. Pittas and colleagues submit the Multi-Center Clinical Study Implementation Planning Cooperating Agreement (U34) grant application to NIH. The goals of the U34 grant are...
![NIDDK allows submission of a U34 planning grant application to plan the D2d study NIDDK allows submission of a U34 planning grant application to plan the D2d study](https://d2dstudy.org/wp-content/uploads/2018/02/2010_0701_D2d_News_Feature-470x320.jpg)
1
Jul
During the spring and early summer of 2010, the D2d concept goes through additional rounds of review within NIDDK. In July of 2010, Dr. Pittas...
![NIDDK Large Studies Committee reviews preliminary concept of D2d NIDDK Large Studies Committee reviews preliminary concept of D2d](https://d2dstudy.org/wp-content/uploads/2018/02/2010_0115_D2d_News_Feature-470x320.jpg)
15
Jan
In December of 2009, Dr. Pittas submits a pre-application to NIDDK proposing the study concept of D2d. The scientific justification of D2d and the preliminary...
2008
![Observational study to examine the association between vitamin D status and future diabetes risk in adults with prediabetes is funded Observational study to examine the association between vitamin D status and future diabetes risk in adults with prediabetes is funded](https://d2dstudy.org/wp-content/uploads/2008/09/NIH_ODS-470x320.jpg)
25
Sep
Dr. Pittas and colleagues receive funding by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the Office of Dietary Supplements (ODS)...
2007
![Observational study to examine the association between vitamin D status and future diabetes risk in women is funded Observational study to examine the association between vitamin D status and future diabetes risk in women is funded](https://d2dstudy.org/wp-content/uploads/2018/02/D2d_News_Feature_NIH_Logo-470x320.png)
31
Jul
Dr. Pittas and colleagues receive funding by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH)...
![Effect of combined Calcium and Vitamin D supplementation in non-diabetic adults is published Effect of combined Calcium and Vitamin D supplementation in non-diabetic adults is published](https://d2dstudy.org/wp-content/uploads/2018/02/original-e1519315399417-470x320.png)
1
Apr
In a post-hoc analysis using data from a completed trial, vitamin D and calcium supplementation given over 3 years improved insulin resistance and fasting blood...
2006
![The CaDDM clinical trial is funded The CaDDM clinical trial is funded](https://d2dstudy.org/wp-content/uploads/2018/02/2006_0930_D2d_News_Feature-470x320.jpg)
30
Sep
Based on strong preliminary data generated by Dr. Pittas and colleagues, the Vitamin D and Calcium Homeostasis for Prevention of Type 2 Diabetes (CaDDM) study...
2002
![Idea is conceived Idea is conceived](https://d2dstudy.org/wp-content/uploads/2018/02/2002_0715_D2d_News_Feature-470x320.jpg)
10
Jul
The idea that vitamin D is linked to risk of developing type 2 diabetes is conceived by Dr. Pittas. In 2002, Dr. Pittas enrolled in...