Our team conducted a post hoc analysis to investigate the relationship between prediabetes, various glycemic classifications, and cardiovascular disease (CVD) risk factors. We analyzed data from 3946 participants in the D2d study to determine how different measures of prediabetes correlated with CVD risk. Our findings showed that individuals with lower insulin sensitivity had a heightened risk of CVD, independent of factors such as age and obesity. Specifically, the Homeostatic Model Assessment 2 of Insulin Sensitivity (HOMA2S) remained significantly associated with atherosclerotic cardiovascular disease (ASCVD) risk scores after adjusting for confounding variables. Additionally, participants meeting multiple criteria for prediabetes exhibited a higher prevalence of metabolic syndrome and elevated ASCVD risk compared to those meeting fewer criteria. Our study underscores the importance of considering various metabolic and glycemic markers in identifying individuals at elevated risk of CVD in the prediabetic stage.
The manuscript is published in the American Journal of Preventive Cardiology.
