Vitamin D Supplementation for Prevention of Type 2 Diabetes Mellitus: To D or Not to D?

The manuscript explains that results from recent trials are congruent with a large body of evidence from observational studies indicating that vitamin D has a role in modulating diabetes risk. Participant-level meta-analysis of the 3 largest trials should provide a...

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Intratrial Exposure to Vitamin D and New-Onset Diabetes Among Adults With Prediabetes: A Secondary Analysis From the Vitamin D and Type 2 Diabetes (D2d) Study

The manuscript explains how postrandomization biases may influence the estimate of efficacy of supplemental vitamin D in diabetes prevention trials. In the Vitamin D and Type 2 Diabetes (D2d) study, repeated measures of serum 25-hydroxyvitamin D level provided...

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Untangling the Gordian Knot of Vitamin D Supplementation and Type 2 Diabetes Prevention

In the commentary Dr. Pittas and Dr. Balk explain that although meta-analyses increase statistical power, allowing more precise effect estimates, for them to be credible certain methodological criteria must be met. Even if the methodology is sound, the strength...

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Reproducibility of a prediabetes classification in a contemporary population

The manuscript explains the present study is a secondary analysis of data from the Vitamin D and Type 2 Diabetes (D2d) Study a large U.S.-based diabetes prevention trial that employed FPG and HbA1c concurrently for the initial identification of...

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D2d Publication: Implications of the Hemoglobin Glycation Index on the Diagnosis of Prediabetes and Diabetes

This analysis used D2d data (individuals with complete screening and baseline visit data) to calculate HGI, identify demographic and clinical variables associated with HGI, and determine how HGI is associated with prediabetes and diabetes diagnosis. These analyses will lay...

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Results of The Primary Outcome Are Unveiled

A presentation of the results took place at the annual American Diabetes Association meeting in San Francisco on Friday, June 7th. Results were published in the New England Journal of Medicine.  

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D2d Publication: Use of Electronic Health Records to Recruit People at High Risk of Type 2 Diabetes

Traditional recruitment of patients with diabetes or prediabetes has included broad, imprecise methods, such as mass mailings, advertisements, community events, and clinician referrals.  The D2d met its enrollment target in a transformative way by utilizing Electronic Health Records (EHR)...

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D2d Participant Visits Completed

The last participant study visit was completed at the Northwestern site. This is a very exciting time for both participants and researchers alike! Since the first participant visit in the fall of 2013, more than 29,401 study visits occurred...

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D2d Publication: Financial Management of large, multi-center trials

Randomized clinical trials that have public health implications but no or low potential for commercial gain are predominantly funded by governmental (e.g., National Institutes of Health (NIH)) and not-for-profit organizations. Judicious management of research studies’ budgets in a milieu...

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D2d Establishes a Participant Registry

A future long-term observational follow-up study (with no pills or visits) is being considered for the purpose of collecting simple health information to learn more about vitamin D and health (e.g., diabetes, cancer, heart disease). In anticipation of this...

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