Oct
19
2020
The manuscript explains that results from recent trials are congruent with a large body of evidence from observational studies indicating that vitamin D has a role in modulating diabetes risk. Participant-level meta-analysis of the 3 largest trials should provide a...
Oct
05
2020
The manuscript explains how postrandomization biases may influence the estimate of efficacy of supplemental vitamin D in diabetes prevention trials. In the Vitamin D and Type 2 Diabetes (D2d) study, repeated measures of serum 25-hydroxyvitamin D level provided...
Jul
01
2020
In the commentary Dr. Pittas and Dr. Balk explain that although meta-analyses increase statistical power, allowing more precise effect estimates, for them to be credible certain methodological criteria must be met. Even if the methodology is sound, the strength...
Mar
21
2020
The manuscript explains the present study is a secondary analysis of data from the Vitamin D and Type 2 Diabetes (D2d) Study a large U.S.-based diabetes prevention trial that employed FPG and HbA1c concurrently for the initial identification of...
Jan
22
2020
This analysis used D2d data (individuals with complete screening and baseline visit data) to calculate HGI, identify demographic and clinical variables associated with HGI, and determine how HGI is associated with prediabetes and diabetes diagnosis. These analyses will lay...
Jun
07
2019
A presentation of the results took place at the annual American Diabetes Association meeting in San Francisco on Friday, June 7th. Results were published in the New England Journal of Medicine.
Apr
22
2019
Traditional recruitment of patients with diabetes or prediabetes has included broad, imprecise methods, such as mass mailings, advertisements, community events, and clinician referrals. The D2d met its enrollment target in a transformative way by utilizing Electronic Health Records (EHR)...
Nov
02
2018
The last participant study visit was completed at the Northwestern site. This is a very exciting time for both participants and researchers alike! Since the first participant visit in the fall of 2013, more than 29,401 study visits occurred...
May
03
2018
Randomized clinical trials that have public health implications but no or low potential for commercial gain are predominantly funded by governmental (e.g., National Institutes of Health (NIH)) and not-for-profit organizations. Judicious management of research studies’ budgets in a milieu...
Apr
06
2018
A future long-term observational follow-up study (with no pills or visits) is being considered for the purpose of collecting simple health information to learn more about vitamin D and health (e.g., diabetes, cancer, heart disease). In anticipation of this...