D2d Publication: Effect of intratrial mean 25(OH)D concentration on diabetes risk, by race and weight: an ancillary analysis in the D2d study.

Continue reading →

D2d Publication: Indices of hepatic steatosis and fibrosis in prediabetes and association with diabetes development in the vitamin D and type 2 diabetes study.

Continue reading →

D2d Publication: The Vitamin D and Risk for Type 2 Diabetes in People With Prediabetes. A Systematic Review and Meta-analysis of Individual Participant Data From 3 Randomized Clinical Trials

Continue reading →

D2d Publication: Effect of vitamin D supplementation on circulating fibroblast growth factor-23 concentration in adults with prediabetes.

Continue reading →

D2d Publication: Safety and tolerability of high-dose daily vitamin D3 supplementation in the vitamin D and type 2 diabetes (D2d) study—a randomized trial in persons with prediabetes

Continue reading →

D2d Publication: Effects of vitamin D supplementation on insulin sensitivity and secretion in prediabetes

Continue reading →

D2d Publication: Effect of Vitamin D Supplementation on Kidney Function in Adults with Prediabetes: A Secondary Analysis of a Randomized Trial

Despite evidence for associations between low circulating 25(OH)D concentration and kidney disease, few clinical trials have evaluated the effect of vitamin D supplementation on kidney outcomes. The Vitamin D and Type 2 Diabetes (D2d) study was a randomized clinical...

Continue reading →

D2d Publication: Vitamin D Supplementation for Prevention of Cancer: The D2d Cancer Outcomes (D2dCA) Ancillary Study

Observational studies suggest that low vitamin D status may be a risk factor for cancer. In a population with prediabetes and overweight/obesity that is at higher risk of cancer than the general population, we sought to determine if vitamin...

Continue reading →

Vitamin D Supplementation for Prevention of Type 2 Diabetes Mellitus: To D or Not to D?

The manuscript explains that results from recent trials are congruent with a large body of evidence from observational studies indicating that vitamin D has a role in modulating diabetes risk. Participant-level meta-analysis of the 3 largest trials should provide a...

Continue reading →

D2d Publication: Intratrial Exposure to Vitamin D and New-Onset Diabetes Among Adults With Prediabetes: A Secondary Analysis From the Vitamin D and Type 2 Diabetes (D2d) Study

The manuscript explains how postrandomization biases may influence the estimate of efficacy of supplemental vitamin D in diabetes prevention trials. In the Vitamin D and Type 2 Diabetes (D2d) study, repeated measures of serum 25-hydroxyvitamin D level provided...

Continue reading →