U01 cooperative agreement grant is submitted

The D2d team submits a U01 grant application to NIH for funding to conduct D2d. Assembling a 1,140-page grant application was a Herculean effort by the D2d planning team. Many scientific, logistical, financial and administrative components came together to...

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Progress of U34 planning phase is reviewed favorably

An External Evaluation Committee convened by NIDDK reviews the progress of the U34 planning phase. The Committee concludes that the D2d team has made excellent progress in designing the D2d study and in preparing for the clinical trial phase....

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Association between higher blood level of vitamin D and lower risk of diabetes among adults with prediabetes is reported

This observational study was to assess the longitudinal association between vitamin D status – assessed by blood level of 25-hydroxyvitamin D – and risk of developing diabetes among people at high risk for diabetes (i.e., with prediabetes). The case-cohort study followed participants...

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The Origin of the D2d logo

The D2d logo was created in the summer of 2011. The three elements (D, 2, d) were chosen to represent the D2d study in the most laconic and memorable way possible. The first “D” stands for vitamin D. The...

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CaDDM clinical trial results are published

Results of the Vitamin D and Calcium Homeostasis for Prevention of Type 2 Diabetes (CaDDM) study support a mechanistic link between vitamin D and diabetes risk among adults at risk for diabetes or with early diabetes not requiring medications. In...

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U34 planning grant is awarded

Dr. Pittas and colleagues are awarded a Multi-Center Clinical Study Implementation Planning Cooperating Agreement (U34) grant. The NIDDK-supported grant provides support to a core team of investigators to finalize the study design, develop the necessary infrastructure and prepare for...

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U34 planning grant application undergoes scientific review

The U34 grant application undergoes a highly favorable scientific peer review by an NIH Special Emphasis Study Section, specifically convened to review the application. Over the next year, NIDDK continues to deliberate the merits of the D2d study and...

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Association between higher blood level of vitamin D and lower risk of diabetes among women is reported

An observational study in the Nurses’ Health Study – a longitudinal cohort of women – supports an association between higher blood level of vitamin D and lower risk of developing diabetes. After adjusting for many factors known to influence diabetes...

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U34 planning grant application is submitted

Dr. Pittas and colleagues submit the Multi-Center Clinical Study Implementation Planning Cooperating Agreement (U34) grant application to NIH.  The goals of the U34 grant are to: (1) Permit early peer review of the rationale for the proposed clinical study;...

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NIDDK allows submission of a U34 planning grant application to plan the D2d study

During the spring and early summer of 2010, the D2d concept goes through additional rounds of review within NIDDK. In July of 2010, Dr. Pittas receives the positive news that NIDDK has approved submission of a Multi-Center Clinical Study...

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