The first meeting of the D2d Research Group is held in Bethesda, MD. Investigators and coordinators from all sites and all supporting units (e.g., central laboratory, central pharmacy) plan a successful study launch.

Tufts Medical Center receives the U01 cooperative agreement grant to fund and conduct D2d. The grant is awarded by NIDDK and the NIH Office of Dietary Supplements. Project Manager Patty Sheehan and Principal Investigator Anastassios Pittas (shown in the...

The inaugural meeting of the D2d Data Safety Monitoring Board (DSMB) takes place in Bethesda, MD. The core D2d team – composed of Dr. Pittas (principal investigator), Dr. Staten (NIH project scientist), Dr. Ware (lead statistician) and Ms. Sheehan...

The U01 grant application seeking funding for D2d undergoes a highly favorable scientific peer review by a NIH Special Emphasis Study Section, specifically convened to review the application. The review panel considers the application “outstanding” and gives a priority...

The D2d team submits a U01 grant application to NIH for funding to conduct D2d. Assembling a 1,140-page grant application was a Herculean effort by the D2d planning team. Many scientific, logistical, financial and administrative components came together to...

An External Evaluation Committee convened by NIDDK reviews the progress of the U34 planning phase. The Committee concludes that the D2d team has made excellent progress in designing the D2d study and in preparing for the clinical trial phase....

This observational study was to assess the longitudinal association between vitamin D status – assessed by blood level of 25-hydroxyvitamin D – and risk of developing diabetes among people at high risk for diabetes (i.e., with prediabetes). The case-cohort study followed participants...

The D2d logo was created in the summer of 2011. The three elements (D, 2, d) were chosen to represent the D2d study in the most laconic and memorable way possible. The first “D” stands for vitamin D. The...

Results of the Vitamin D and Calcium Homeostasis for Prevention of Type 2 Diabetes (CaDDM) study support a mechanistic link between vitamin D and diabetes risk among adults at risk for diabetes or with early diabetes not requiring medications. In...

Dr. Pittas and colleagues are awarded a Multi-Center Clinical Study Implementation Planning Cooperating Agreement (U34) grant. The NIDDK-supported grant provides support to a core team of investigators to finalize the study design, develop the necessary infrastructure and prepare for...