The D2d logo was created in the summer of 2011. The three elements (D, 2, d) were chosen to represent the D2d study in the most laconic and memorable way possible. The first “D” stands for vitamin D. The...

Results of the Vitamin D and Calcium Homeostasis for Prevention of Type 2 Diabetes (CaDDM) study support a mechanistic link between vitamin D and diabetes risk among adults at risk for diabetes or with early diabetes not requiring medications. In...

Dr. Pittas and colleagues are awarded a Multi-Center Clinical Study Implementation Planning Cooperating Agreement (U34) grant. The NIDDK-supported grant provides support to a core team of investigators to finalize the study design, develop the necessary infrastructure and prepare for...

The U34 grant application undergoes a highly favorable scientific peer review by an NIH Special Emphasis Study Section, specifically convened to review the application. Over the next year, NIDDK continues to deliberate the merits of the D2d study and...

An observational study in the Nurses’ Health Study – a longitudinal cohort of women – supports an association between higher blood level of vitamin D and lower risk of developing diabetes. After adjusting for many factors known to influence diabetes...

Dr. Pittas and colleagues submit the Multi-Center Clinical Study Implementation Planning Cooperating Agreement (U34) grant application to NIH.  The goals of the U34 grant are to: (1) Permit early peer review of the rationale for the proposed clinical study;...

During the spring and early summer of 2010, the D2d concept goes through additional rounds of review within NIDDK. In July of 2010, Dr. Pittas receives the positive news that NIDDK has approved submission of a Multi-Center Clinical Study...

In December of 2009, Dr. Pittas submits a pre-application to NIDDK proposing the study concept of D2d. The scientific justification of D2d and the preliminary study design go through multiple rigorous reviews by scientific committees within NIDDK, starting in...

Dr. Pittas and colleagues receive funding by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the Office of Dietary Supplements (ODS) of the National Institutes of Health (NIH) to assess the longitudinal association between vitamin D status...

Dr. Pittas and colleagues receive funding by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH) to assess the longitudinal association between vitamin D status – assessed by blood level of 25-hydroxyvitamin...